Article
No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2002
Takahashi Hitoshi, Yoshida Keizo, Ito Kenich, Sato Kazuhiro, Kamata Mitsuhiro, Higuchi Hisashi, Shimizu Tetsuo, Ito Kunihiko, Inoue Kazuyuki, Tezuka Takehiko, Suzuki Toshio, Ohkubo Tadashi, Sugawara Kazunobu
Abstract excerpt
We investigated the association between serotonergic polymorphisms and incidence of nausea, which is the most frequent side-effect of selective serotonin reuptake inhibiters (SSRIs), in 66 patients treated with fluvoxamine in a protocolized-dosing method. We focused on three polymorphisms of serotonin (5-HT) neuronal systems such as 5-HT transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), a variable...
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