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Article

The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?

Medical hypotheses - 1 Sept 2002

Manning J T, Bundred P E, Flanagan B F

Abstract excerpt

The androgen receptor gene (AR) contains a domain which includes a variable number of CAG sequences and alleles with low numbers of CAG repeats show high transactivation activity when complexed with testosterone. The ratio of 2nd and 4th digit length (2D:4D) is negatively correlated with phenotypic effects of testosterone. Low numbers of CAG repeats and low 2D:4D are both associated with high sperm numbers and...

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Identifiers

PMID: 12208164
DOI: 10.1016/s0306-9877(02)00181-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene?PMID 12208164Read ↗

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The second to fourth digit ratio and variation in the androgen receptor geneSemantic proximity Read ↗

Androgen receptor: an overview.Semantic proximity Read ↗

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero.Semantic proximity Read ↗

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Re-examining the Manning hypothesis: androgen receptor polymorphism and the 2D:4D digit ratioSemantic proximity Read ↗

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