Article
Maternal diabetes increases the risk of caudal regression caused by retinoic acid.
Diabetes - 1 Sept 2002
Chan Billy W H, Chan Kwok-Siu, Koide Tsuyoshi, Yeung Sau-Man, Leung Maran B W, Copp Andrew J, Loeken Mary R, Shiroishi Toshihiko, Shum Alisa S W
Abstract excerpt
Maternal diabetes increases the risk of congenital malformations in the offspring of affected pregnancies. This increase arises from the teratogenic effect of the maternal diabetic milieu on the developing embryo, although the mechanism of this action is poorly understood. In the present study, we examined whether the vitamin A metabolite retinoic acid (RA), a common drug with well-known teratogenic properties,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.