Article
A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27.
American journal of human genetics - 1 Oct 2002
Auranen Mari, Vanhala Raija, Varilo Teppo, Ayers Kristin, Kempas Elli, Ylisaukko-Oja Tero, Sinsheimer Janet S, Peltonen Leena, Järvelä Irma
Abstract excerpt
To identify genetic loci for autism-spectrum disorders, we have performed a two-stage genomewide scan in 38 Finnish families. The detailed clinical examination of all family members revealed infantile autism, but also Asperger syndrome (AS) and developmental dysphasia, in the same set of families. The most significant evidence for linkage was found on chromosome 3q25-27, with a maximum two-point LOD score of 4.31...
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