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Article

Chaperone proteins abrogate inhibition of the human papillomavirus (HPV) E1 replicative helicase by the HPV E2 protein.

Molecular and cellular biology - 1 Sept 2002

Lin Biing Yuan, Makhov Alexander M, Griffith Jack D, Broker Thomas R, Chow Louise T

Abstract excerpt

Human papillomavirus (HPV) DNA replication requires the viral origin recognition protein E2 and the presumptive viral replicative helicase E1. We now report for the first time efficient DNA unwinding by a purified HPV E1 protein. Unwinding depends on a supercoiled DNA substrate, topoisomerase I, single-stranded-DNA-binding protein, and ATP, but not an origin. Electron microscopy revealed completely unwound...

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Identifiers

PMID: 12192057
DOI: 10.1128/MCB.22.18.6592-6604.2002
PMCID: PMC135630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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