Article
Biological phenotype determination with ex vivo model in gastric cancer for matrix-metalloproteinase inhibitor treatment.
International journal of molecular medicine - 1 Sept 2002
Rha Sun Young, Jeung Hei Cheul, Roh Jae Kyung, Kim Jin Ju, Noh Sung Hoon, Min Jin Sik, Kim Byung Soo, Chung Hyun Cheol
Abstract excerpt
Among the many biological characteristics of cancer, matrix-metalloproteinases (MMPs) are essential for tumor invasion and metastasis. To test the possibility of ex vivo model as a therapeutic guideline for MMP inhibitor (MMPI) treatment, we evaluated IC50 of the gabexate mesylate against MMP-9. Thirty-four paired normal and gastric cancer tissues were tested to measure the IC50 of the gabexate mesylate. MMP-9...
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