Article
Yeast cells lacking the ARV1 gene harbor defects in sphingolipid metabolism. Complementation by human ARV1.
The Journal of biological chemistry - 27 Sept 2002
Swain Evelyn, Stukey Joseph, McDonough Virginia, Germann Melody, Liu Ying, Sturley Stephen L, Nickels Joseph T
Abstract excerpt
arv1Delta mutant cells have an altered sterol distribution within cell membranes (Tinkelenberg, A.H., Liu, Y., Alcantara, F., Khan, S., Guo, Z., Bard, M., and Sturley, S. L. (2000) J. Biol. Chem. 275, 40667-40670), and thus it has been suggested that Arv1p may be involved in the trafficking of sterol in the yeast Saccharomyces cerevisiae and also in humans. Here we present data showing that arv1Delta mutants also...
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