Article
Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila.
Genetics - 1 Jul 2002
Palladino Michael J, Hadley Tricia J, Ganetzky Barry
Abstract excerpt
Age-dependent neurodegeneration is a pathological condition found in many metazoans. Despite the biological and medical significance of this condition, the cellular and molecular mechanisms underlying neurodegeneration are poorly understood. The availability of a large collection of mutants exhibiting neurodegeneration will provide a valuable resource to elucidate these mechanisms. We have developed an effective...
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