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Article

Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.

Biochemical pharmacology - 15 Jul 2002

Wang Chiu-Ya, Lei Huey-Jing, Huang Chi-Ying Fred, Zhang Zhongjian, Mukherjee Anil B, Yuan Chiun-Jye

Abstract excerpt

The induction of cyclooxygenase-2 (COX-2) plays a crucial role in many physiological and pathological processes. The expression of the COX-2 gene is regulated by many extracellular stimuli, including growth factors, cytokines, and tumor promoters. Staurosporine, a potential anti-tumor drug, was f...

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Source

Identifiers

PMID: 12123737
DOI: 10.1016/s0006-2952(02)01106-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12123737-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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