Article
Direct haplotype detection of adjacent polymorphic sites in the regulatory region of the dopamine D4 receptor (DRD4) gene.
Electrophoresis - 1 May 2002
Ronai Zsolt, Guttman András, Nemoda Zsofia, Gervai Judit, Sasvari-Szekely Maria
Abstract excerpt
A novel method of haplotype identification is discussed allowing simultaneous detection of two adjacent polymorphic sites, a single nucleotide polymorphism (SNP) and a length polymorphism within 1-2 kilobase distance. The method combines allele specific-amplification with high-throughput, automated ultrathin-layer gel electrophoresis analysis of fragment size polymorphism. A typical application is shown for...
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