Article
Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers.
International journal of cancer - 20 Jul 2002
Oji Yusuke, Miyoshi Shinichiro, Maeda Hajime, Hayashi Seiji, Tamaki Hiroya, Nakatsuka Shin-Ichi, Yao Masayuki, Takahashi Eigo, Nakano Yoko, Hirabayashi Hirohisa, Shintani Yasushi, Oka Yoshihiro, Tsuboi Akihiro, Hosen Naoki, Asada Momotaro, Fujioka Tatsuya, Murakami Masaki, Kanato Keisuke, Motomura Mari, Kim Eui Ho, Kawakami Manabu, Ikegame Kazuhiro, Ogawa Hiroyasu, Aozasa Katsuyuki, Kawase Ichiro, Sugiyama Haruo
Abstract excerpt
Expression of the Wilms' tumor gene WT1 in de novo lung cancer was examined using quantitative real-time RT-PCR and immunohistochemistry. Overexpression of the WT1 gene was detected by RT-PCR in 54/56 (96%) de novo non-small cell lung cancers examined and confirmed by detection of WT1 protein with an anti-WT1 antibody. Overexpression of the WT1 gene was also demonstrated in 5/6 (83%) de novo small cell lung...
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