Article
Cyp6a8 of Drosophila melanogaster: gene structure, and sequence and functional analysis of the upstream DNA.
Insect biochemistry and molecular biology - 1 Aug 2002
Maitra Sushmita, Price Charles, Ganguly Ranjan
Abstract excerpt
In Drosophila, the insecticide resistant 91-R strain is an overproducer and susceptible 91-C and ry(506) strains are the underproducers of CYP6A8 mRNA encoded by a cytochrome P450 gene, Cyp6a8. Low expression of Cyp6a8 in the underproducer strains is due to a downregulatory effect of a putative repressor locus, which is thought to be mutant in the overproducer strain. In the present investigation, organization of...
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