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Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua.

PLoS genetics - 1 Mar 2021

Hu Bo, Huang He, Hu Songzhu, Ren Miaomiao, Wei Qi, Tian Xiangrui, Esmail Abdalla Elzaki Mohammed, Bass Chris, Su Jianya, Reddy Palli Subba

Abstract excerpt

The evolution of insect resistance to insecticides is frequently associated with overexpression of one or more cytochrome P450 enzyme genes. Although overexpression of CYP450 genes is a well-known mechanism of insecticide resistance, the underlying regulatory mechanisms are poorly understood. Here we uncovered the mechanisms of overexpression of the P450 gene, CYP321A8 in a major pest insect, Spodoptera exigua...

Topics

Animals
Base Sequence
Cytochrome P-450 Enzyme System
Gene Expression Regulation
Insect Proteins
Insecticide Resistance
Insecticides
Mutation
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spodoptera

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Identifiers

PMID: 33690635
DOI: 10.1371/journal.pgen.1009403
PMCID: PMC7978377

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