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Article

Conformation nearby Trp residues of APIA and APIB modulates the inhibitory specificity of the protease.

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica - 1 Jul 2002

Li Jiong, Chi Cheng-Wu, Ruan Kang-Cheng

Abstract excerpt

The relationship between the micro-environment of the two tryptophan residues and the inhibitory specificity of arrowhead protease inhibitors A and B (APIA and APIB) was studied by mutagenesis and fluorescence spectroscopy. The environment of the two Trp residues at positions 93 and 122 in APIB is more hydrophobic than in APIA. Study after substitution of Trp with Ala revealed that the environment of Trp(122) is...

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PMID: 12098774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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