Article
Direct detection of potential selenium delivery proteins by using an Escherichia coli strain unable to incorporate selenium from selenite into proteins.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002
Lacourciere Gerard M, Levine Rodney L, Stadtman Thressa C
Abstract excerpt
Selenium can be metabolized for protein synthesis by two major pathways in vivo. In a specific pathway it can be inserted into polypeptide chains as the amino acid selenocysteine, as directed by the UGA codon. Alternatively, selenium can be substituted for sulfur to generate the free amino acids selenocysteine and selenomethionine, and these are incorporated nonspecifically into proteins in place of cysteine and...
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