Article
No evidence of mutations in the CACNA1S gene in the UK malignant hyperthermia population.
British journal of anaesthesia - 1 Apr 2002
Brooks C, Robinson R L, Halsall P J, Hopkins P M
Abstract excerpt
BACKGROUND: Malignant hyperthermia (MH) is an inherited, potentially fatal, pharmocogenetic disorder triggered by certain anaesthetic agents. In light of the reported genetic heterogeneity for the disorder and the recent introduction of DNA testing guidelines for the trait, we have assessed the role of the CACNA1S gene in MH susceptibility in UK patients. Linkage to this locus has previously been demonstrated in...
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