Article
Genetics and hypogonadotrophic hypogonadism.
Current opinion in obstetrics & gynecology - 1 Jun 2002
Hay Cathy, Wu Frederick
Abstract excerpt
Hypothalamic pulsatile gonadotrophin-releasing hormone secretion, stimulating pituitary gonadotrophin secretion, is essential for adult reproductive function. This neuroendocrine drive to the reproductive axis is critically dependent on a sequence of developmental events in utero. During early foetal life, gonadotrophin-releasing hormone neurones migrate from the nasal placode to the medial basal hypothalamus...
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