Rabies virus glycoprotein can fold in two alternative, antigenically distinct conformations depending on membrane-anchor type.

Abstract excerpt

Rabies virus glycoprotein (G) is a trimeric type I transmembrane glycoprotein that mediates both receptor recognition and low pH-induced membrane fusion. We have previously demonstrated that a soluble form of the ectodomain of G (G(1-439)), although secreted, is folded in an alternative conformation, which is monomeric and antigenically distinct from the native state of the complete, membrane-anchored...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibodies, Viral
• Share to Antigens, Viral
• Share to Endoplasmic Reticulum