Multiple mechanisms for the activation of human platelet aggregation by <i>Staphylococcus aureus</i>: roles for the clumping factors ClfA and ClfB, the serine–aspartate repeat protein SdrE and protein A

Abstract excerpt

The ability of Staphylococcus aureus cells to induce platelet aggregation has long been recognized. However, despite several attempts to identify the mechanisms involved in this interaction, the nature of the bacterial receptors required remains poorly understood. Using genetic manipulation, this study for the first time provides clear evidence that several S. aureus surface proteins participate in the...

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