Article
Epithelia-mesenchyme interaction plays an essential role in transdifferentiation of retinal pigment epithelium of silver mutant quail: localization of FGF and related molecules and aberrant migration pattern of neural crest cells during eye rudiment formation.
Developmental biology - 15 Apr 2002
Araki Masasuke, Takano Takako, Uemonsa Tomoko, Nakane Yoshifumi, Tsudzuki Masaoki, Kaneko Tomoko
Abstract excerpt
Homozygotes of the quail silver mutation, which have plumage color changes, also display a unique phenotype in the eye: during early embryonic development, the retinal pigment epithelium (RPE) spontaneously transdifferentiates into neural retinal tissue. Mitf is considered to be the responsible gene and to function similarly to the mouse microphthalmia mutation, and tissue interaction between RPE and surrounding...
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