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Article

ActP controls copper homeostasis in Rhizobium leguminosarum bv. viciae and Sinorhizobium meliloti preventing low pH-induced copper toxicity.

Molecular microbiology - 1 Feb 2002

Reeve Wayne G, Tiwari Ravi P, Kale Neetin B, Dilworth Michael J, Glenn Andrew R

Abstract excerpt

Two 'calcium-irreparable' acid-sensitive mutants were identified after mutagenizing Rhizobium leguminosarum bv. viciae and Sinorhizobium meliloti with Tn5. Each mutant contains a single copy of the transposon which, inserted within the actP gene, prevents expression of a P-type ATPase that belongs to the CPx heavy metal-transporting subfamily. Here, we show that both actP-knockout mutants show sensitivity to...

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PMID: 11936079
DOI: 10.1046/j.1365-2958.2002.02791.x

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