Article
Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein
1 Jan 2002
Abstract excerpt
We have investigated the potential utility of monoclonal antibodies against mini-chromosome maintenance-2 protein (Mcm2) in predicting meningioma recurrence. MCM proteins are members of the DNA-binding prereplicative complex and are essential for eukaryotic DNA replication. They are present throughout the cell cycle, but are down-regulated in quiescence and cell differentiation, making them specific markers of...
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