Article
Sequence polymorphism of dotA and mip alleles mediating invasion and intracellular replication of Legionella pneumophila.
Current microbiology - 1 May 2002
Bumbaugh Alyssa C, McGraw Elizabeth A, Page Kristen L, Selander Robert K, Whittam Thomas S
Abstract excerpt
Legionella pneumophila inhabit a variety of natural and man-made aquatic environments, where they live primarily as intracellular parasites of protozoans. Given the proper exposure, however, they can cause opportunistic pneumonic infections in humans. The products of two L. pneumophila genes, dotA and mip, are part of the mechanism mediating the initial invasion of eukaryotic cells, and subsequent intracellular...
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