Article
The role of genotype in determining the effects of cigarette smoking on pulmonary function.
Genetic epidemiology - 1 Mar 2002
Tishler Peter V, Carey Vincent J, Reed Terry, Fabsitz Richard R
Abstract excerpt
The effect of cigarette smoking on pulmonary function is highly variable. Some heavy smokers retain normal pulmonary function and others experience profound pulmonary function loss. The role of genotype in this process is unknown. We tested for gene by environment interaction (GxE) in smoking-associated loss of forced expiratory volume in one second (FEV1) using repeated pulmonary function and smoke-exposure...
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