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Article

Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding.

The Journal of biological chemistry - 14 Jun 2002

Lee Soojin, Fan Chun Yang, Younger J Michael, Ren Hongyu, Cyr Douglas M

Abstract excerpt

Sis1 is an essential yeast Type II Hsp40 protein that assists cytosolic Hsp70 Ssa1 in the facilitation of processes that include translation initiation, the prevention of protein aggregation, and proteasomal protein degradation. An essential function of Sis1 and other Hsp40 proteins is the binding and delivery of non-native polypeptides to Hsp70. How Hsp40s function as molecular chaperones is unknown. The crystal...

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PMID: 11919183
DOI: 10.1074/jbc.M111075200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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