<i>Helicobacter pylori</i> Uses Motility for Initial Colonization and To Attain Robust Infection

Abstract excerpt

Helicobacter pylori has been shown to require flagella for infection of the stomach. To analyze whether flagella themselves or motility is needed by these pathogens, we constructed flagellated nonmotile mutants. This was accomplished by using both an insertion mutant and an in-frame deletion of the motB gene. In vitro, these mutants retain flagella (Fla(+)) but are nonmotile (Mot(-)). By using FVB/N mice, we...

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