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Article

The topology of the possible: formal spaces underlying patterns of evolutionary change.

Journal of theoretical biology - 21 Nov 2001

Stadler B M, Stadler P F, Wagner G P, Fontana W

Abstract excerpt

The current implementation of the Neo-Darwinian model of evolution typically assumes that the set of possible phenotypes is organized into a highly symmetric and regular space equipped with a notion of distance, for example, a Euclidean vector space. Recent computational work on a biophysical genotype-phenotype model based on the folding of RNA sequences into secondary structures suggests a rather different...

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PMID: 11894994
DOI: 10.1006/jtbi.2001.2423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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