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Article

Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.

International journal of oncology - 1 Apr 2002

Saitoh Tetsuroh, Mine Tetsuya, Katoh Masaru

Abstract excerpt

FRAT1 and FRAT2 genes, clustered in human chromosome 10q24, are human homologues to mouse proto-oncogene Frat1, which promotes carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway. FRAT1 and FRAT2 mRNAs are up-regulated together in a gastric cancer cell line TMK1, and also in 2 out of 10 cases of primary gastric cancer. Here, we isolated FRAT1 cDNA (AB074890), which showed two...

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Source

Identifiers

PMID: 11894125

Genes

FRAT1
FRAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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