Article
Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection.
Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002
Chan Kaman, Knaak Timothy, Satkamp Laura, Humbert Olivier, Falkow Stanley, Ramakrishnan Lalita
Abstract excerpt
During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes within granulomas. We analyzed the gene expression profile of Mycobacterium marinum, the cause...
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