Article
[From gene to disease; the dystrophin gene involved in Duchenne and Becker muscular dystrophy].
Nederlands tijdschrift voor geneeskunde - 23 Feb 2002
den Dunnen J T, de Visser M, Bakker E
Abstract excerpt
Duchenne and Becker muscular dystrophy (DMD and BMD) are progressive disorders, which almost exclusively affect males. DMD is the more severe type with an onset at 2-3 years of age. Patients become wheelchair-bound before the age of 13 and often die due to cardiac arrest or respiratory insufficiency. BMD, a more varying phenotype which may overlap with limb girdle muscular dystrophy (LGMD), has a less severe...
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