Article
Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
JAMA - 27 Feb 2002
Verlinsky Yury, Rechitsky Svetlana, Verlinsky Oleg, Masciangelo Christina, Lederer Kevin, Kuliev Anver
Abstract excerpt
CONTEXT: Indications for preimplantation genetic diagnosis (PGD) have recently been expanded to include disorders with genetic predisposition to allow only embryos free of predisposing genes to be preselected for transfer back to patients, with no potential for pregnancy termination. OBJECTIVE: To perform PGD for early-onset Alzheimer disease (AD), determined by nearly completely penetrant autosomal dominant...
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