Article
Issues in molecular genetic testing of individuals with suspected early-onset familial Alzheimer's disease.
Alzheimer disease and associated disorders - 1 Jan 1994
Karlinsky H, Sadovnick A D, Burgess M M, Langlois S, Hayden M R, Berg J M
Abstract excerpt
The identification of mutations in the amyloid precursor protein (APP) gene associated with the presence of early-onset familial Alzheimer disease (AD) raises the possibility of their practical clinical application, at least in some circumstances, in the diagnostic assessment for AD. As a stimulus for discussion, a hypothetical, illustrative case vignette is presented. A 48-year-old man, concerned about recent...
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