Article
A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.
Blood - 1 Mar 2002
Schuh Andre C, Watkins Nick A, Nguyen Quang, Harmer Nicholas J, Lin Martin, Prosper Joseph Y A, Campbell Kate, Sutherland D Robert, Metcalfe Paul, Horsfall Wendy, Ouwehand Willem H
Abstract excerpt
The biallelic platelet-specific Gov antigen system-implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura-is carried by the glycosylphosphatidylinositol (GPI)-linked protein CD109. The recent identification of the human CD109 complementary DNA (cDNA) has allowed the molecular nature of the Gov alleles to be elucidated. By using reverse...
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