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Article

Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Zhou Tong, Carlson J M, Doyle John

Abstract excerpt

We introduce a model of evolution in which competing organisms are represented by percolation lattice models. Fitness is based on the number of occupied sites remaining after removing a cluster connected to a randomly selected site. High-fitness individuals arising through mutation and selection must trade off density versus robustness to loss, and are characterized by cellular barrier patterns that prevent large...

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Identifiers

PMID: 11842230
DOI: 10.1073/pnas.261714399
PMCID: PMC122317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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