The complex structure and dynamic evolution of human subtelomeres.

doi:10.1038/nrg727

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Article

The complex structure and dynamic evolution of human subtelomeres.

Nature reviews. Genetics - 1 Feb 2002

Mefford Heather C, Trask Barbara J

Abstract excerpt

Subtelomeres are extraordinarily dynamic and variable regions near the ends of chromosomes. They are defined by their unusual structure: patchworks of blocks that are duplicated near the ends of multiple chromosomes. Duplications among subtelomeres have spawned small gene families, making inter-individual variation in subtelomeres a potential source of phenotypic diversity. The ectopic recombination that occurs...

Topics

Animals
Biological Evolution
Ethnicity
Gene Rearrangement
Genetic Diseases, Inborn
Genetic Variation
Humans
In Situ Hybridization, Fluorescence
Models, Genetic
Multigene Family
Polymerase Chain Reaction
Primates
Recombination, Genetic
Telomere

Source

Open in PubMed

Identifiers

PMID: 11836503
DOI: 10.1038/nrg727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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