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Article

Structure and cooperativity of a T-state mutant of histidine decarboxylase from Lactobacillus 30a.

Proteins - 15 Feb 2002

Worley Scott, Schelp Elisabeth, Monzingo Arthur F, Ernst Stephen, Robertus Jon D

Abstract excerpt

Histidine decarboxylase (HDC) from Lactobacillus 30a converts histidine to histamine, a process that enables the bacteria to maintain the optimum pH range for cell growth. HDC is regulated by pH; it is active at low pH and inactive at neutral to alkaline pH. The X-ray structure of HDC at pH 8 revealed that a helix was disordered, resulting in the disruption of the substrate-binding site. The HDC trimer has also...

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Source

Identifiers

PMID: 11835507
DOI: 10.1002/prot.10042

Genes

HDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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