Evidence of Nucleoside Analogue Reverse Transcriptase Inhibitor–Associated Genetic and Structural Defects of Mitochondria in Adipose Tissue of HIV-Infected Patients

Abstract excerpt

To investigate if possible mitochondrial injury can be found in adipose tissue of nucleoside analogue reverse transcriptase inhibitor (NRTI)-treated patients, subcutaneous fat was taken from the buttocks of 24 HIV-positive patients and 8 HIV-negative controls. The content of mitochondrial DNA (mtDNA) was quantified using a Southern blot technique. Fat biopsies were examined by electron microscopy and screened by...

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