Article
Interglandular cytogenetic heterogeneity detected by comparative genomic hybridization in pancreatic cancer.
Cancer research - 1 Feb 2002
Harada Tomohiko, Okita Kiwamu, Shiraishi Kei, Kusano Noriyoshi, Kondoh Satoshi, Sasaki Kohsuke
Abstract excerpt
The aim of this study is to explore the mechanisms of intratumoral cytogenetic heterogeneity (ICH) in pancreatic cancer. Using comparative genomic hybridization (CGH) analysis, we investigated interglandular variation in 20 primary invasive ductal adenocarcinomas of the pancreas. Three or four adjacent neoplastic glands were individually microdissected from a tumor specimen. Extracted DNA from each gland was...
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