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Article

The extracellular signal-regulated kinase (ERK) pathway is involved in human sperm function and modulated by the superoxide anion

1 Feb 2002

Abstract excerpt

Our aim was to ascertain the role of the extracellular signal-regulated protein kinase (ERK) pathway in human sperm capacitation induced by fetal cord serum ultrafiltrate (FCSu) and its regulation by the superoxide anion (O(2)(-)*). Immunoblotting indicated the presence of Shc, Grb2, Ras(p21), Raf and ERK1 and 2 (ERK1/2) in spermatozoa. Grb2, Ras(p21), Raf and MEK inhibitors dose-dependently prevented sperm...

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PMID: 11818515
DOI: 10.1093/molehr/8.2.124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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