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Article

Complete Development of Mosquito Phases of the Malaria Parasite in Vitro

25 Jan 2002

Abstract excerpt

Methods for reproducible in vitro development of the mosquito stages of malaria parasites to produce infective sporozoites have been elusive for over 40 years. We have cultured gametocytes of Plasmodium berghei through to infectious sporozoites with efficiencies similar to those recorded in vivo and without the need for salivary gland invasion. Oocysts developed extracellularly in a system whose essential...

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PMID: 11809973
DOI: 10.1126/science.1067159

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