Article
The Ess1 prolyl isomerase is required for growth and morphogenetic switching in Candida albicans.
Genetics - 1 Jan 2002
Devasahayam Gina, Chaturvedi Vishnu, Hanes Steven D
Abstract excerpt
Prolyl-isomerases (PPIases) are found in all organisms and are important for the folding and activity of many proteins. Of the 13 PPIases in Saccharomyces cerevisiae only Ess1, a parvulin-class PPIase, is essential for growth. Ess1 is required to complete mitosis, and Ess1 and its mammalian homolog, Pin1, interact directly with RNA polymerase II. Here, we isolate the ESS1 gene from the pathogenic fungus Candida...
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