Article
Alkylating agent (MNU)-induced mutation in space environment.
Advances in space research : the official journal of the Committee on Space Research (COSPAR) - 1 Jan 2001
Ohnishi T, Takahashi A, Ohnishi K, Takahashi S, Masukawa M, Sekikawa K, Amano T, Nakano T, Nagaoka S
Abstract excerpt
In recent years, some contradictory data about the effects of microgravity on radiation-induced biological responses in space experiments have been reported. We prepared a damaged template DNA produced with an alkylating agent (N-methyl-N-nitroso urea; MNU) to measure incorrect base-incorporation during DNA replication in microgravity. We examined whether mutation frequency is affected by microgravity during DNA...
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