Article
Vascular endothelial cell growth factor-driven endothelial tube formation is mediated by vascular endothelial cell growth factor receptor-2, a kinase insert domain-containing receptor.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2001
Yang S, Xin X, Zlot C, Ingle G, Fuh G, Li B, Moffat B, de Vos A M, Gerritsen M E
Abstract excerpt
Vascular endothelial cell growth factor (VEGF) binds to 2 related receptor tyrosine kinases, known as kinase insert domain-containing receptor (KDR) and fms-like tyrosine kinase (Flt-1). The KDR has been shown to mediate VEGF-stimulated endothelial cell mitogenesis, migration, and permeability. The Flt-1 receptor has been suggested to mediate VEGF-stimulated endothelial branching morphogenesis, a process whereby...
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