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Article

Immune Evasion by Muscle-Specific Gene Expression in Dystrophic Muscle

1 Dec 2001

Abstract excerpt

Muscle tissue from Duchenne muscular dystrophy patients and the Dmd(mdx/mdx) (hereafter referred to as mdx) mouse is characterized by an abundance of necrotic myofibers and infiltrating macrophages. Both features may provide additional stimulus to the immune response directed against novel antigens, such as those delivered by gene therapy vectors. It has previously been shown that the immune evasion achieved by...

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Identifiers

PMID: 11735336
DOI: 10.1006/mthe.2001.0496

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