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Article

CpG-depleted adeno-associated virus vectors evade immune detection

16 Jun 2013

Abstract excerpt

Due to their efficient transduction potential, adeno-associated virus (AAV) vectors are leading candidates for gene therapy in skeletal muscle diseases. However, immune responses toward the vector or transgene product have been observed in preclinical and clinical studies. TLR9 has been implicated in promoting AAV-directed immune responses, but vectors have not been developed to circumvent this barrier. To assess...

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PMID: 23778142
DOI: 10.1172/jci68205

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