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Article

Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein.

The Journal of biological chemistry - 25 Jan 2002

Mo Yin-Yuan, Yu Yanni, Shen Zhiyuan, Beck William T

Abstract excerpt

DNA topoisomerase (topo) I is an essential nuclear protein and a target for anticancer drug camptothecin derivatives. As a nuclear protein, topo I is concentrated in the nucleolus. However, this nucleolar distribution of topo I is dynamic. It has been shown recently that topo I rapidly moves out of the nucleolus (nucleolar delocalization) in response to topo I inhibitors. In the present study, we demonstrated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11709553
DOI: 10.1074/jbc.M108263200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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