Article
Holoprosencephaly: the Maastricht experience.
Genetic counseling (Geneva, Switzerland) - 1 Jan 2001
Moog U, De Die-Smulders C E, Schrander-Stumpel C T, Engelen J J, Hamers A J, Frints S, Fryns J P
Abstract excerpt
Holoprosencephaly (HPE) is a developmental field defect with impaired cleavage of the embryonic forebrain as the cardinal feature. The prevalence is about 1 in 11.000-20.000 in live births and 1 in 250 during embryogenesis. In most cases, craniofacial abnormalities are associated and reflect in 80% of cases the degree of severity. The severity is of marked variability and ranges from cyclopia to minimal...
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