Article
Restoration of function of carboxy-terminally truncated pseudorabies virus glycoprotein B by point mutations in the ectodomain.
Journal of virology - 1 Dec 2001
Nixdorf R, Klupp B G, Mettenleiter T C
Abstract excerpt
Glycoprotein B (gB) of pseudorabies virus (PrV) is essential for virus entry into target cells and direct viral cell-to-cell spread. Recently, we described a carboxy-terminally truncated derivative of PrV gB, gB-007, which was inefficiently incorporated into virions, was unable to complement infectivity, but was fully capable of restoring direct viral cell-to-cell spread of gB-negative PrV (R. Nixdorf, B. G....
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Primers
- Genome, Viral
- Herpesvirus 1, Suid
- Phenotype
- Point Mutation
- Precipitin Tests
- Viral Envelope Proteins
- Viral Plaque Assay