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Article

Killing of sarcoma cells by proapoptotic Bcl-X(S): role of the BH3 domain and regulation by Bcl-X(L).

Neoplasia (New York, N.Y.) - 1 Jan 2000

Mitra R S, Benedict M A, Qian D, Foreman K E, Ekhterae D, Nickoloff B J, Nuñez G

Abstract excerpt

Kaposi's sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease. Previous studies have demonstrated that KS tumor cells predominantly express the prosurvival protein Bcl-X(L) compared with Bcl-2. In the current study, we have used an adenoviral vector that expresses Bcl-X(S), a functional inhibitor of Bcl-X(L), to study the significance of Bcl-X(L)...

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Identifiers

PMID: 11687955
DOI: 10.1038/sj.neo.7900181
PMCID: PMC1506204

Genes

SLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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