Article
Vitamin D receptor gene polymorphism detected by digestion with Apa I influences the parathyroid response to extracellular calcium in Japanese chronic dialysis patients.
Nephron - 1 Nov 2001
Yokoyama K, Shigematsu T, Kagami S, Tsukada T, Arai T, Hara S, Yamada A, Kawaguchi Y, Hosoya T
Abstract excerpt
BACKGROUND: To play its physiological role, 1,25(OH)2D3 must bind to a specific vitamin D receptor (VDR) in the nucleus. We have previously reported that VDR gene polymorphism influences the parathyroid function in patients with end-stage renal disease (ESRD). In the present study, we have investigated the relationship between the parathyroid responsiveness and VDR gene polymorphism, as detected by the Apa I...
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